Nowadays there is an increasing use of the digital setting in various fields, including psychology and pedagogy. Author's purpose is to explore different forms of digital setting applications, describing their possibility of usage and eventually their limitations. First of all, the authors are going to define the concept of Artificial Intelligence (AI) and the possibility of using it in clinical settings. Then, the authors will proceed to describe the application of Artificial Intelligence and Augmented Reality both in assessment and in prevention of cognitive function decline. The application of digital settings for treatment in the field of mental health will also be discussed, both for adult people and for young people; in addition, the ethical issues, in particular for e-therapies, will be debated. Lastly, another way of application of digital setting is for access to education; for this reason, the authors will explain the teaching approaches that use the virtual.