The article points out a contribution to the psychoanalytic interpretation of schizophrenia, particularly about its various ethiological and pathogenetic factors, that psychoanalysis can question only partially, regarding its contribution the psychological and environmental factors like emerging at a re-construction level. Neverthless, that contribution is important in order to address neurological, pharmacological and epidemiological research and to accomplish a deeper under standing of mind-brain relationship, as well as neuroscientific research and its results are needful for achieving a new psychoanalytic metapsychology. The model wich the author refers to is the Self sistemic-processual psychoanalytic model (Elia, 1999), based on the integration of the first Freud’s topic reformulated by Bucci’s Multiple Code Theory (1997), with the structural theory (Ego, Id, Super-ego, Ideal Egosub-systems).