The authors, under the form of an interview, present data and insights from their research and clinical experience with the use of new pharmacological treatments for substance use disorders. A common understanding of the interviewee is that the reverse process of the neuro-adaptation to these substances works through appropriate integrated care interventions, i.e. pharmacological and psychosocial, which allow therapeutic work on addiction memoirs. The results of this approach can be either the cessation of drug use, or the reduction of the compulsive consumption. The misuse of opioid analgesics and more in general iatrogenic addictions are nowadays a worrying aspect of the new frontier of clinical interventions in addiction.
Keywords: Substance use disorders (SUD), alcohol use disorders (AUD), addiction memoirs, posttraumatic stress disorder (PTSD), reverse engineering