The concept of autism as a multifactorial disease with a crucial emphasis on the impact of the environment is emerging. Removing environmental factors such as pollution, inflammatory food, chronic infections, and heavy metals, while supporting reduction of oxidative stress and detoxification, have shown to be effective for some children diagnosed with autism. A chronically activated brain inflammation usually persists even if the reason for this activation has been removed. Hence, it needs a combined strategy of intervention aimed to shut down the inflammation in the brain.
Keywords: Autism, multifactiorial disease, environment, epidemic, inflammation, encephalopathy, activated microglia, mast cell, biomedical thera