Click here to download

Autism: a disease of the body and not only a disorder of the mind
Journal Title: PNEI REVIEW 
Author/s: Nicola Antonucci 
Year:  2017 Issue: Language: Italian 
Pages:  6 Pg. 41-46 FullText PDF:  1084 KB
DOI:  10.3280/PNEI2017-001005
(DOI is like a bar code for intellectual property: to have more infomation:  clicca qui   and here 

The concept of autism as a multifactorial disease with a crucial emphasis on the impact of the environment is emerging. Removing environmental factors such as pollution, inflammatory food, chronic infections, and heavy metals, while supporting reduction of oxidative stress and detoxification, have shown to be effective for some children diagnosed with autism. A chronically activated brain inflammation usually persists even if the reason for this activation has been removed. Hence, it needs a combined strategy of intervention aimed to shut down the inflammation in the brain.
Keywords: Autism, multifactiorial disease, environment, epidemic, inflammation, encephalopathy, activated microglia, mast cell, biomedical thera

  1. American Psychiatric Association (2013) Diagnostic and statistical manual of mental disorders. 5th ed, Arlington, VA.
  2. Christensen DL, Baio J, Van Naarden Braun K, et al. (2016) Prevalence and Characteristics of Autism Spectrum Disorder Among Children Aged 8 Years--Autism and Developmental Disabilities Monitoring Network, 11 Sites, United States, 2012, MMWR Surveill Summ 65(3):1-23.
  3. Fiorentino M, Sapone A, Senger S, et al. (2016) Blood-brain barrier and intestinal epithelial barrier alterations in autism spectrum disorders, Mol Autism 7:49.
  4. Kanner L e Eiseberg L (1957) Early infantile autism, 1943-1955, Psychiatr Res Rep Am Psychiatr Assoc (7):55-65.
  5. Jyonouchi H. (2010) Autism spectrum disorders and allergy: observation from a pediatric allergy/immunology clinic, Expert Rev Clin Immunol 6(3):397-411.
  6. Nardone S e Elliott E (2016) The Interaction between the Immune System and Epigenetics in the Etiology of Autism Spectrum Disorders, Front Neurosci 10:329.
  7. Schendel DE, Overgaard M, Christensen J, et al. (2016) Association of Psychiatric and Neurologic Comorbidity With Mortality Among Persons With Autism Spectrum Disorder in a Danish Population, JAMA Pediatr 170(3):243-50. 2015.3935
  8. Theoharides TC, Asadi S e Patel AB (2013) Focal brain infl ammation and autism, J Neuroinfl ammation 10:46.
  9. Theoharides TC, Tsilioni I, Patel Ab, et al. (2016) Atopic diseases and infl ammation of the brain in the pathogenesis of autism spectrum disorders, Transl Psychiatry (6):e844.
  10. Yuen RK, Thiruvahindrapuram B, Merico D, et al. (2015) Whole-genome sequencing of quartet families with autism spectrum disorder, Nat Med 21(2):185-91.

Nicola Antonucci, Autism: a disease of the body and not only a disorder of the mind in "PNEI REVIEW" 1/2017, pp. 41-46, DOI:10.3280/PNEI2017-001005


FrancoAngeli is a member of Publishers International Linking Association a not for profit orgasnization wich runs the CrossRef service, enabing links to and from online scholarly content