The paper presents a reflection of the cultural and economic changes invested in contemporary society. Starting from the digital culture, a specific attention is focused on the relations between the underway innovation and new opportunities - and challenges - grouping around the system of training. On this topic the paper is concerned with digital and entrepreneurial skills. The paper presents the Contamination Lab experience, which began in Italian Universities in 2013 with the main objective of promoting entrepreneurship and innovation culture aiming at the beginning and the support of new startups. The paper explores the interactions between possible educational scenarios and contemporary social, economic and cultural contexts. Sceneries that are fed of innovation, creativeness and connection.
Keywords: Contamination, digital culture, entrepreneurship, innovation