Low grade chronic inflammation (LGCI) is a very common condition; the incidence is proportional to age. Patients with chronic inflammatory disease have a higher risk of cardiovascular disease (CVD) and related mortality. Cardiovascular risk factors are of course a key factor for the onset of CVD; however, LGC acts independently: it accelerates atherosclerosis, favors myocardial infarction, cerebrovascular disease and heart failure (HF). Modulation of systemic system inflammation goes through various interventions: nutrition, exercise, microbiota control, stress modulation. A promising role is attributed to low-dose therapy that uses low doses of natural principles and biological molecules such as cytokines, neuropeptides, hormones and growth factors.
Keywords: Chronic inflammation, low-grade inflammation, cardiovascular diseases, microbiota, mitochondria, low-dose therapy