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Pnei of pregnancy and delivery: from physiological to pathological aspects
Journal Title: PNEI REVIEW 
Author/s: Maria Luigia Spinelli, Emilia Bonacini 
Year:  2019 Issue: Language: Italian 
Pages:  12 Pg. 6-17 FullText PDF:  104 KB
DOI:  10.3280/PNEI2019-002002
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Apart from physiological and somatic changes, pregnancy is a complex phenomenon which also includes psychological and social changes. Psychosocial stress during the pregnancy can be the triggering event of a bad placentation, endangering the fetus wellbeing or health. This can result in pathological condition including intrauterine growth restriction (IUGR) or premature birth. Stress can also have consequences on the delivery, influencing the physiological mechanisms that orchestrate the eutocic birth. Here the authors review some of the evidence of the psychoneuroendocrinoimmunology (Pnei) of pregnancy and delivery, spacing from physiological to pathological aspects. Paying attention to any emotional and psychological changes during pregnancy will help keep mother and baby safe and healthy.
Keywords: Pregnancy, Preterm birth, IUGR, Labour, Stress, Pnei.

  1. Aguilar H.N. and Mitchell B.F. (2010). Physiological pathways and molecular mechanism regulating uterine contractility. Human. Reprod., 16(6): 725-744.
  2. American College of Obstetricians and Gynecologists. (2012) ACOG practice bulletin no. 127: Management of preterm labor. Obstet. Gynecol., 119(6): 1308-1317.
  3. Copper R.L., Goldenberg R.L, Das A., Elder N., Swain M., Norman G., Ramsey R., Cotroneo
  4. P., Collins B.A., Johnson F., Jones P. and Meier A.M. (1996). The preterm prediction study: maternal stress is associated with spontaneous preterm birth at less than thirty-five weeks’ gestation. National Institute of Child Health and Human Development Maternal-Fetal Medicine Units Network. Am. J. Obstet. Gynecol., 175(5): 1286-1292.
  5. Crowther C.A., Aghajafari F., Askie L.M., Asztalos E.V., Brocklehurst P., Bubner T.K., Doyle L.W., Dutta S., Garite T.J., Guinn D.A., Hallman M., Hannah M.E., Hardy P., Maurel K., Mazumder P., McEvoy C., Middleton P.F., Murphy K.E., Peltoniemi O.M., Peters D., Sullivan L., Thom E.A., Voysey M., Wapner R.J., Yelland L. and Zhang S. (2012). Repeat prenatal corticosteroid prior to preterm birth: a systematic review and individual participant data meta-analysis for the PRECISE study group (prenatal repeat corticosteroid international IPD study group: assessing the effects using the best level of evidence) – study protocol. Syst. Rev., 1:12., DOI: 10.1186/2046-4053-1-1
  6. De Franco E.A., Lewis D.F. and Odibo A.O. (2013). Improving the screening accuracy for preterm labor: is the combination of fetal fibronectin and cervical length in symptomatic patients a useful predictor in preterm birth? A systematic review. Am. J. Obstet. Gynecol., 208(3): 233-236.
  7. Hoirisch-Clapauch S., Brenner B. and Nardi A.E. (2015). Adverse obstetric and neonatal outcomes in women with mental disorders. Thromb. Res., 135 Suppl 1: S60-S63., DOI: 10.1016/S0049-3848(15)50446-
  8. Iliodromiti Z., Antonakopoulos N., Sifakis S., Tsikouras P., Daniilidis A., Dafopoulos K., Botsis D. and Vrachnis N. (2012). Endocrine, paracrine and autocrine placental mediators in labor. Hormones, 11(4): 397-409.
  9. Nabavizadeh S.H., Malekzadeh M., Mousavizadeh A., Shirazi H.R., Ghaffari P., Karshenas N., Malekzadeh T. and Zoladl M. (2012). Retrospective study of factors related to preterm labor in Iran. Int. J. Gen. Med., 5: 1013-1017.
  10. Su Q., Zhang H., Zhang Y., Zhang H., Ding D., Zeng J., Zhu Z. and Li H. (2015). Maternal Stress in Gestation: Birth Outcomes and Stress-Related Hormone Response of the Neonates. Pediatr. Neonatol., 56(6): 376-381.
  11. Vicino B., Adenzato M., Ardito R.B. (2015). Programmi di prevenzione e trattamento per madri di bambini nati pretermine: stato dell’arte e prospettive alla luce della teoria dell’attaccamento. Quaderni di Psicoterapia Cognitiva, 36: 85-102., DOI: 10.3280/QPC2015-03600
  12. Voltolini C., Torricelli M., Comi N., Vellucci F.L., Severi F.M. and Petraglia F. (2013). Understanding spontaneous preterm birth: from underlying mechanism to predictive and preventive interventions. Reprod. Sci., 20(11): 1274-1292., DOI: 10.1177/193371911347749

Maria Luigia Spinelli, Emilia Bonacini, Pnei of pregnancy and delivery: from physiological to pathological aspects in "PNEI REVIEW" 2/2019, pp. 6-17, DOI:10.3280/PNEI2019-002002


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