Click here to download

Inflammation and social inequalities
Journal Title: PNEI REVIEW 
Author/s:  Paolo Vineis 
Year:  2020 Issue: Language: Italian 
Pages:  5 Pg. 49-53 FullText PDF:  100 KB
DOI:  10.3280/PNEI2020-001006
(DOI is like a bar code for intellectual property: to have more infomation:  clicca qui   and here 


Lifepath is a multi-cohort consortium on the biological impact of social inequalities. Disadvantaged socioeconomic position (SEP) can create long term effects through physiological wear-and-tear involving inflammatory responses, impaired immune function and epigenetic acceleration of ageing. Data from the 1958 British birth cohort indicated that lower maternal education, manual paternal occupation and adverse childhood experiences (ACE) were associated with a higher allostatic load at 44 years. The association of ACE with allostatic load was strongly mediated by health behaviours and education level at 23 years and SEP at 33 years. Disadvantaged SEP was associated with accelerated ageing as assessed through DNA methylation, and biological ageing was more rapid in individuals with fewer years in education. Individuals with life-course SEP improvement had intermediate levels of accelerated ageing compared to extreme SEP categories, suggesting possible reversibility of the effect. These findings show the value of using biological markers to understand the relationship between social factors and health.
Keywords: Lifepath, Adverse childhood experiences, Allostatic load, DNA methylation, Socioeconomic position, Ageing.

  1. Barboza Solís C., Fantin R., Kelly-Irving M. and Delpierre C. (2016). Physiological wear-and-tear and later subjective health in mid-life: Findings from the 1958 British birth cohort. Psychoneuroendocrinology, 74: 24-33.
  2. Barboza Solís C., Kelly-Irving M., Fantin R., Darnaudery M., Torrisani J., Lang T. and Delpierre C. (2015). Adverse childhood experiences and physiological wear- andtear in midlife: Findings from the 1958 British birth cohort. Proc. Natl. Acad. Sci. USA, 112(7): E738-E746.
  3. Berger E., Castagne R., Chadeau-Hyam M., Bochud M., d’Errico A., Gandini M., Karimi M., Kivimäki M., Krogh V., Marmot M., Panico S., Preisig M., Ricceri F., Sacerdote C., Steptoe A., Stringhini S., Tumino R., Vineis P., Delpierre C. and Kelly-Irving M. (2019). Multi-cohort study identifies social determinants of systemic inflammation over the life course. Nat. Commun., 10 (1): 773.
  4. Dugue P.A., Bassett J.K., Joo J.E., Baglietto L., Jung C.H., Wong E.M., Fiorito G., Schmidt D., Makalic E., Li S., Moreno-Betancur M., Buchanan D.D., Vineis P., English D.R., Hopper J.L., Severi G., Southey M.C., Giles G.G. and Milne R.L. (2018). Association of DNA Methylation-Based Biological Age With Health Risk Factors and Overall and Cause-Specific Mortality. Am. J. Epidemiol., 187(3): 529-538.
  5. Fiorito G., Polidoro S., Dugué P.A., Kivimaki M., Ponzi E., Matullo G., Guarrera, S., Assumma M.B., Georgiadis P., Kyrtopoulos S.A., Krogh V., Palli D., Panico S., Sacerdote C., Tumino R., Chadeau-Hyam M., Stringhini S., Severi G., Hodge A.M., Giles G.G., Marioni R., Karlsson Linnér R., O’Halloran A.M., Kenny R.A., Layte R., Baglietto L., Robinson O., McCrory C., Milne R.L. and Vineis P. (2017). Social adversity and epigenetic aging: a multi-cohort study on socioeconomic differences in peripheral blood DNA methylation. Sci. Rep., 7(1): 16391-16395.
  6. Fiorito G., McCrory C., Robinson O., Carmeli C., Rosales C.O., Zhang Y., Colicino E., Dugué P.A., Artaud F., McKay G.J., Jeong A., Mishra P.P., Nøst T.H., Krogh V., Panico S., Sacerdote C., Tumino R., Palli D., Matullo G., Guarrera S., Gandini M., Bochud M., Dermitzakis E., Muka T., Schwartz J, Vokonas P.S., Just A., Hodge A.M., Giles G.G., Southey M.C., Hurme M.A., Young I., McKnight A.J., Kunze S., Waldenberger M., Peters A., Schwettmann L., Lund E., Baccarelli A., Milne R.L., Kenny R.A., Elbaz A., Brenner H., Kee F., Voortman T., Probst-Hensch N., Lehtimäki T., Elliot P., Stringhini S., Vineis P., Polidoro S.; BIOS Consortium; Lifepath consortium. (2019). Socioeconomic position, lifestyle habits and biomarkers of epigenetic aging: a multi-cohort analysis. Aging (Albany NY), 11(7): 2045-2070.
  7. Vineis P., Avendano-Pabon M., Barros H., Bartley M., Carmeli C., Carra L., Chadeau-Hyam M., Costa G., Delpierre C., D’Errico A., Fraga S., Giles G., Goldberg M., Kelly-Irving M., Kivimaki M., Lepage B., Lang T., Layte R., MacGuire F., Mackenbach J.P., Marmot M., McCrory C., Milne R.L., Muennig P., Nusselder W., Petrovic D., Polidoro S., Ricceri F., Robinson O., Stringhini S. and Zins M. (2020). Special Report: The Biology of Inequalities in Health: The Lifepath Consortium. Front. Public Health, 8: 118.
  8. Vineis P., Delpierre C., Castagné R., Fiorito G., McCrory C., Kivimaki M., Stringhini S., Carmeli C. and Kelly-Irving M. (2020b). Health inequalities: Embodied evidence across biological layers. Soc. Sci. Med., 246: 112781.

Paolo Vineis, Inflammation and social inequalities in "PNEI REVIEW" 1/2020, pp. 49-53, DOI:10.3280/PNEI2020-001006

   

FrancoAngeli is a member of Publishers International Linking Association a not for profit orgasnization wich runs the CrossRef service, enabing links to and from online scholarly content