The role of brain drainage in the pathogenesis of neuroinflammatory/neurodegenerative diseases is largely unknown. Recently, in the central nervous system (CNS) the so-called g-lymphatic system (nomenclature derived from the fundamental role of the glia) has been identified. It allows the drainage of the cerebrospinal fluid, peptides and toxins respectively into the venous system and the meningeal and deep cervical lymphatics, as demonstrated in the last few years. Such recent discoveries now allow to hypothesize a crucial role of the hemo-lymphatic drainage system of the CNS in the process of neuroinflammation and/or neurodegeneration. This article reports the most current knowledge that links the pathophysiology of the g-lymphatic system of the CNS to neurodegenerative diseases (Parkinson’s, Alzheimer’s, multiple sclerosis, etc.). Finally, the possibilities and limits of some therapeutic options, from a Pnei point of view, aimed at improving the flow of the cerebro-spinal lymph are exposed.
Keywords: G-lymphatic system, Cerebrospinal flu