The stress response, by releasing glucocorticoids and catecholamines and modifying the endocrine, neural and immune functions, can affect the body structure, at both tissue and cellular level. In particular, through the involvement of the immune system, the stress response can alter the structure of fascia, a kind of connective tissue located everywhere in the organism that perform paramount architectural and communication roles for every organ. In the present article, by analyzing the stress response, the immune system and the connective tissue, the Authors carry out a review of these interactions under the lens of Pnei to highlight how body structure and function are tightly intertwined. A specific attention will be paid to how fascia, muscles and bones are affected by the stress response and to how lifestyle can play a determinant role in this dynamic.
Keywords: Stress, Immune system, Fascia, Connective tissue, Myofibroblasts, Mechanobiology.