Autism and autism spectrum disorders (ASD) include complex neurodevelopmental disorders characterized by cognitive, social interaction and communication, language defects and behavioral problems. The interaction between genetic and environmental factors is the basis of this disorder, although the pathogenesis is not yet entirely clear. A series of biochemical events are associated with autism, as well as immune dysfunction and gastrointestinal problems. The inflammatory and immune-mediated component is particularly important in the development of these disorders. Recent evidences emphasize that the endocannabinoid system is a key molecular component and regulator of immune and inflammatory dysfunction.
Keywords: Autism, endocannabinoids, neuro-immunomodulation