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The potential of vegan diets as an instrument for prevention and treatment
Journal Title: PNEI REVIEW 
Author/s: Giordana Garuzzo, Ilaria Demori 
Year:  2017 Issue: Language: Italian 
Pages:  11 Pg. 104-114 FullText PDF:  1117 KB
DOI:  10.3280/PNEI2017-002010
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Dietary habits in the so-called Western world have undergone a genuine revolution over the last decades: once rich in plant foods and low in animal products and derivatives, our diets are now marked by the ubiquitous presence of meat and refi ned grains, while fruits and vegetables play a marginal role. As a result, the risk of developing diseases such as diabetes, cancer or cardiovascular, neurodegenerative and autoimmune disorders has increased. Recent studies have shown that the typical features of a vegan diet - protein and calorie restriction, reduction of inflammation and a healthier gut microbiota - allow to prevent, improve and halt the progress of the most common chronic conditions in the developed world. This article describes the molecular mechanisms behind the protective potential that is nowadays associated to a 100% plant based diet, emphasizing that, as long as we supplement it with vitamin B12, a vegan diet is healthy and complete, and satisfies all physiological needs at all life stages.
Keywords: Vegan diet, protein restriction, inflammation, microbiota, micronutrients, vitamin B12.

  1. Baroni L. (2016). La vitamina B12 nelle diete vegetariane. Testo disponibile al sito:, in data 23/08/2017.
  2. Allen N.E., Appleby P.N., Davey G.K., Kakks R., Rinaldi S. and Key T.J. (2002). The associations of diet with serum insulin-like growth factor I and its main binding proteins in 292 women meat-eaters, vegetarians, and vegans. Cancer Epidemiol. Biomarkers Prev., 11(11): 1441-1448.
  3. Baselga-Escudero L., Souza-Mello V., Pascual-Serrano A., Rachid, T. Voci A., Demori I. and Grasselli, E. (2017). Benefi cial effects of the Mediterranean spices and aromas on nonalcoholic fatty liver disease. TIFS, 61:141-159., 10.1016/J.TIFS.2016.11.01DOI: 10.1016/J.TIFS.2016.11.01
  4. Berrino F. (2015a). Il cibo dell’uomo. Milano: Franco Angeli.
  5. Berrino F. (2015b). Alimentazione e malattie croniche: la sindrome metabolica come paradigma. PNEI Review, 1: 4253.
  6. Bjerknes R. and Aarskog D. (1995). Priming of human polymorphonuclear neutrophilic leukocytes by insulinlike growth factor I: increased phagocytic capacity, complement receptor expression, degranulation, and oxidative burst. J. Clin. Endocrinol. Metab., 80: 1948-1955., 10.1210/JCEM.80.6.777564DOI: 10.1210/JCEM.80.6.777564
  7. Bottaccioli F. e Bottaccioli A.G. (2017) Psiconeuroendocrinoimmunologia e scienza della cura integrata. Il manuale. Milano: Edra.
  8. Dewell A., Weidner G., Sumner M.D. (2007). Relationship of dietary protein and soy isoflavonesto serum IGF-1 and IGF binding proteins in the prostate cancer lifestyle trial. Nutr. Cancer, 58(1): 35-42., 10.1080/0163558070130803DOI: 10.1080/0163558070130803
  9. Diamond J. (2013). Il mondo fi no a ieri. Torino: Einaudi.
  10. Domouzoglou E.M. and Maratos-Flier E. (2011). Fibroblast growth factor 21 is a metabolic regulator that plays a role in the adaptation to ketosis. Am. J. Clin. Nutr., 93(4): 901S-905S., 10.3945/AJCN.110.00194DOI: 10.3945/AJCN.110.00194
  11. Elorinne A-L., Alfthan G., Erlund I., Kivimäki H., Paju A., Salminen I., Turpeinen U., Voutilainen S. and Laakso J. (2016). Food and Nutrient Intake and Nutritional Status of Finnish Vegans and Non-Vegetarians. PLoS One, 11(2): e0148235., 10.1371/JOURNAL.PONE.014823DOI: 10.1371/JOURNAL.PONE.014823
  12. Esser N., Legrand-Poels S., Piette J., Scheen A.J. and Paquot N. (2014). Inflammation as a link between obesity, metabolic syndrome and type 2 diabetes. Diab. Res. Clin. Pract., 105(2): 141-150., 10.1016/J.DIABRES.2014.04.00DOI: 10.1016/J.DIABRES.2014.04.00
  13. Fontana L. (2009). Neuroendocrine factors in the regulation of inflammation: excessive adiposity and calorie restriction. Exp. Gerontol., 44(1-2): 41-45., 10.1016/J.EXGER.2008.04.00DOI: 10.1016/J.EXGER.2008.04.00
  14. Glick-Bauer M. and Yeh M.C. (2014). The health advantage of a vegan diet: exploring the gut microbiota connection. Nutrients, 6(11): 4822-4838., 10.3390/NU611482DOI: 10.3390/NU611482
  15. Han J.M., Jeong S.J., Park M.C., Kim G., Kwon N.H., Kim H.K., Ha S.H., Ryu S.H. and Kim S. (2012). Leucyl-tRNA synthetase is an intracellular leucine sensor for them-TORC1-signalling pathway. Cell, 149(2): 410-424., 10.1016/J.CELL.2012.02.04DOI: 10.1016/J.CELL.2012.02.04
  16. Heaney R.P. and Layman D.K. (2008). Amount and type of protein influences bone health. Am. J. Clin. Nutr., 87(5): 1567S-1570S.
  17. Junnila R.K., List E.O., Berryman D.E., Murray J.W. and Kopchick J.J. (2013). The GH/IGF-1 axis in ageing and longevity. Nat. Rev. Endocrinol., 9(6): 366-376., 10.1038/NRENDO.2013.6DOI: 10.1038/NRENDO.2013.6
  18. Kelley K.W., Arkins S., Minshall C., Liu Q. and Dantzer R. (1996). Growth hormone, growth factors and hematopoiesis. Horm. Res., 45(1-2): 38-45., 10.1159/00018475DOI: 10.1159/00018475
  19. Kellum J.A., Song M. and Li J. (2004). Science review: Extracellular acidosis and the immune response: clinical and physiologic implications. Critic. Care, 8(5): 331-336., 10.1186/CC290DOI: 10.1186/CC290
  20. Kim M.S., Hwang S.S., Park E.J. and Bae J.W. (2013), Strict vegetarian diet improves the risk factors associated with metabolic diseases by modulating gut microbiota and reducing intestinal inflammation. Environ. Microbiol. Rep., 5(5): 765-775., 10.1111/1758-2229.1207DOI: 10.1111/1758-2229.1207
  21. Kjeldsen-Kragh J. (1999). Rheumatoid arthritis treated with vegetarian diets. Am J of Clin. Nutr., 70 [3 Suppl.]: 594S-600S.
  22. Kjeldsen-Kragh J., Haugen M., Borchgrevink C.F., Laerum E., Eek M., Mowinkel P., Hovi K. and Førre O. (1991). Controlled trial of fasting and one-year vegetarian diet in rheumatoid arthritis. Lancet, 338(8772): 899-902. 10.1016/0140-6736(91)91770-U
  23. Koeth R.A., Wang Z., Levison B.S., Buffa J.A., Org E., Sheehy B.T., Britt E.B., Fu X., Wu Y., Li L., Smith J.D., DiDonato J.A., Chen J., Li H., Wu G.D., Lewis J.D., Warrier M., Brown J.M., Krauss R.M., Tang W.H., Bushman F.D., Lusis A.J. and Hazen S.L. (2013). Intestinal microbiota metabolism of L-carnitine, a nutrient in red meat, promotes atherosclerosis, Nat. Med., 19(5): 576-585., 10.1038/NM.314DOI: 10.1038/NM.314
  24. Kohlenberg-Mueller K. and Raschka L. (2003). Calcium balance in young adults on a vegan and lactovegetarian diet. J. Bone Miner. Metab., 21(1): 28-33., 10.1007/S00774030000DOI: 10.1007/S00774030000
  25. Larsson C.L. and Johansson G.K. (2002). Dietary intake and nutritional status of young vegans and omnivores in Sweden. Am. J. Clin. Nutr., 76(1): 100-106.
  26. Maslowski K.M. and Mackay C.R. (2011). Diet, gut microbiota and immune responses. Nat. Immunol., 12(1): 59., 10.1038/NI0111-DOI: 10.1038/NI0111-
  27. Matijašić B.B., Obermajer T., Lipoglavšek L., Grabnar I., Avguštin G. and Rogelj I. (2014). Association of dietary type with fecal microbiota in vegetarians and omnivores in Slovenia. Eur. J. Nutr., 53(4): 1051-1064., 10.1007/S00394-013-0607-DOI: 10.1007/S00394-013-0607-
  28. McCarty M.F. (1999). Vegan proteins may reduce risk of cancer, obesity, and cardiovascular disease by promoting increased glucagon activity. Med. Hypoth., 53(6): 459-485., 10.1054/MEHY.1999.078DOI: 10.1054/MEHY.1999.078
  29. McCarty M.F. (2011). MTORC1 activity as a determinant of cancer risk-rationalizing the cancer-preventive effects of adiponectin, metformin, rapamycin, and low protein vegan diets. Med. Hypoth., 77(4): 642648., 10.1016/J.MEHY.2011.07.00DOI: 10.1016/J.MEHY.2011.07.00
  30. McCarty M.F. (2014). GCN2 and FGF21 are likely mediators of the protection from cancer, autoimmunity, obesity, and diabetes afforded by vegan diets. Med. Hypoth., 83(3): 365-371., 10.1016/J.MEHY.2014.06.01DOI: 10.1016/J.MEHY.2014.06.01
  31. McDougall J., Thomas L.E., McDougall C., Moloney G., Saul B., Finnell J.S., Richardson K. and Petersen K.M. (2014). Effects of 7 days on an ad libitum low-fat vegan diet: the McDougall Program cohort. Nutr. J., 13: 99., 10.1186/1475-2891-13-9DOI: 10.1186/1475-2891-13-9
  32. Melina V., Craig W. and Levin S. (2016). Position of the Academy of Nutrition and Dietetics: Vegetarian Diets. J. Acad. Nutr. Diet., 116(12): 1970-1980., 10.1016/J.JAND.2016.09.02DOI: 10.1016/J.JAND.2016.09.02
  33. Nishimura T., Nakatake Y., Konishi M. and Itoh N. (2000). Identification of a novel FGF, FGF-21, preferentially expressed in the liver. Biochim. Biophys. Acta., 1492(1): 203-206., 10.1016/S0167-4781(00)00067-DOI: 10.1016/S0167-4781(00)00067-
  34. Peltonen R., Kjeldsen-Kragh J., Haugen M., Tuominen J., Toivanen P., Førre O. and Eerola E. (1994). Changes of faecal flora in rheumatoid arthritis during fasting and one-year vegetarian diet. Br. J. Rheumatol., 33(7): 638-643., 10.1093/RHEUMATOLOGY/33.7.63DOI: 10.1093/RHEUMATOLOGY/33.7.63
  35. Peltonen R., Nenonen M., Helve T., Hänninen O., Toivanen P. and Eerola E. (1997). Faecal microbial fl ora and disease activity in rheumatoid arthritis during a vegan diet. Br. J. Rheumatol., 36(1): 64-68., 10.1093/RHEUMATOLOGY/36.1.6DOI: 10.1093/RHEUMATOLOGY/36.1.6
  36. Piccoli G.B., Clari R., Vigotti F.N., Leone F., Attini R., Cabiddu G., Mauro G., Castelluccia N., Colombi N., Capizzi I., Pani A., Todros T. and Avagnina P. (2015). Vegan-vegetarian diets in pregnancy: danger or panacea? A systematic narrative review. BJOG, 122(5): 623-633., 10.1111/1471-0528.1328DOI: 10.1111/1471-0528.1328
  37. Sahota O. (2014). Understanding vitamin D deficiency. Age Ageing, 43(5): 589-591., 10.1093/AGEING/AFU10DOI: 10.1093/AGEING/AFU10
  38. Seltenrich N. (2015). New link in the food chain? Marine plastic pollution and seafood safety. Environ. Health Perspect., 123(2): A34-A41., 10.1289/EHP.123-A3DOI: 10.1289/EHP.123-A3
  39. Sheehan M.C., Burke T.A., Navas-Acien A., Breysse P.N., McGready J. and Fox M.A. (2014). Global methylmercury exposure from seafood consumption and risk of developmental neurotoxicity: a systematic review. Bull. World Health Organ., 92(4): 254F269F., 10.2471/BLT.12.11615DOI: 10.2471/BLT.12.11615
  40. Società Scientifi ca di Nutrizione Vegetariana (2017). Il Piatto Veg. Testo disponibile al sito:, in data 23/08/2017.
  41. Sofi F., Macchi C., Abbate R., Gensini G.F. and Casini A. (2014). Mediterranean diet and health status: an updated meta-analysis and a proposal for a literature-based adherence score. Public Health Nutr., 17(12): 2769-2782., 10.1017/S136898001300316DOI: 10.1017/S136898001300316
  42. Sutliffe J.T., Wilson L.D., de Heer H.D., Foster R.L. and Carnot M.J. (2015). Creactive protein response to a vegan lifestyle intervention. Compl. Ther. Med., 23(1): 32-37., 10.1016/J.CTIM.2014.11.00DOI: 10.1016/J.CTIM.2014.11.00
  43. UNESCO (2013). Mediterranean diet. Text available on site:, in data 23/08/2017.
  44. Zhang H. and Tsao R. (2016). Dietary polyphenols, oxidative stress and antioxidant and antiinflammatory effects. Curr. Opin. Food. Sci., 8: 33-42., 10.1016/J.COFS.2016.02.00DOI: 10.1016/J.COFS.2016.02.00

Giordana Garuzzo, Ilaria Demori, The potential of vegan diets as an instrument for prevention and treatment in "PNEI REVIEW" 2/2017, pp. 104-114, DOI:10.3280/PNEI2017-002010


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