Clicca qui per scaricare

L’asse psiche-cervello-sistema immunitario al servizio dell’adattamento dell’organismo all’ambiente: l’importanza delle interazioni fra infiammazione e comportamento sociale
Titolo Rivista: PNEI REVIEW 
Autori/Curatori: Andrea Minelli, Michael Di Palma 
Anno di pubblicazione:  2018 Fascicolo: Lingua: Italiano 
Numero pagine:  15 P. 31-45 Dimensione file:  1146 KB
DOI:  10.3280/PNEI2018-002003
Il DOI è il codice a barre della proprietà intellettuale: per saperne di più:  clicca qui   qui 


I processi infiammatori e il comportamento sociale si influenzano reciprocamente. I fattori pro-infi ammatori, citochine in primis, inducono un concerto di modifi cazioni comportamentali che aiutano l’organismo a navigare l’ambiente sociale durante periodi di malattia, aumentando la sensibilità dei circuiti neurali di salienza/allarme agli stimoli sociali negativi (per identifi care ed evitare prontamente potenziali pericoli) e la reattività dei circuiti di reward agli stimoli sociali positivi (per favorire l’approccio verso fi gure di supporto e protezione). Viceversa, gli eventi avversi di natura sociale, come abusi, separazioni, esclusione sociale, valutazioni negative, possono indurre un incremento dell’infi ammazione periferica (per preparare l’organismo a situazioni di aumentato rischio di ferite o infezioni). Individui socialmente isolati, o che si sentono tali, presentano un cronico incremento dei livelli di infi ammazione, e un’esagerata produzione di fattori proinfi ammatori in risposta a infezioni e a esperienze sociali avverse. Ciò può avere implicazioni rilevanti sul piano clinico e spiegare la relazione fra stress cronico, infi ammazione e alcune malattie neuropsichiatriche caratterizzate da compromissione del funzionamento sociale, quali ansia e depressione.


Keywords: Psiconeuroendocrinoimmunologia, Stress, Allostasi, Carico allostatico, Cervello sociale, Depressione.

  1. Antoni M.H., Lutgendorf S.K., Blomberg B., Carver C.S., Lechner S., Diaz A., Stagl J., Arevalo J.M. and Cole S.W. (2012). Cognitive-behavioral stress management reverses anxiety-related leukocyte transcriptional dynamics. Biol. Psychiatry, 71(4): 366-372.
  2. Aschbacher K., Epel E., Wolkowitz O.M., Prather A.A., Puterman E. and Dhabhar F.S. (2012). Maintenance of a positive outlook during acute stress protects against proinfl ammatory reactivity and future depressive symptoms. Brain Behav. Immun., 26(2): 346-352.
  3. Black D.S. and Slavich G.M. (2016). Mindfulness meditation and the immune system: a systematic review of randomized controlled trials. Ann. N.Y. Acad. Sci., 1373(1): 13-24.
  4. Bottaccioli A.G., Bottaccioli F. and Minelli A. (2018). Stress and the psyche-brainimmune network in psychiatric diseases based on psychoneuroendocrinoimmunlogy: a concise review. Ann NY Acad. Sci. [Epub ahead of print]
  5. Bottaccioli F. e Bottaccioli A.G. (2017). Psiconeuroendocrinoimmunologia e scienza della cura integrata. Il Manuale. Milano: Edra.
  6. Cacioppo J.T., Cacioppo S., Capitanio J.P. and Cole S.W. (2015). The neuroendocrinology of social isolation. Annu. Rev. Psychol., 66: 733-767.
  7. Carpenter L.L., Gawuga C.E., Tyrka A.R. and Price L.H. (2012). C-reactive protein, early life stress, and wellbeing in healthy adults. Acta Psychiatr. Scand., 126(6): 402-10.
  8. Carroll J.E., Low C.A., Prather A.A., Cohen S., Fury J.M., Ross D.C. and Marsland A.L. (2011). Negative affective responses to a speech task predict changes in interleukin (IL)-6. Brain Behav. Immun., 25(2): 232-238.
  9. Chiang J.J., Eisenberger N.I., Seeman T.E. and Taylor S.E. (2012). Negative and competitive social interactions are related to heightened proinfl ammatory cytokine activity. PNAS, 109(6): 1878-1882.
  10. Cole S.W. (2006). The complexity of dynamic host networks. In: Deisboeck T.S. and Kresh J.Y., eds., Complex Systems Science in Biomedicine. New York: Springer US., 10.1007/978-0-387-33532-2_26DOI: 10.1007/978-0-387-33532-2_26
  11. Cole S.W. (2014). Human social genomics. PLoS Genet., 10(8): e1004601.
  12. Del Rey A. and Besedowsky H. (2014). The immune-neuroendocrine network in health and disease. In: Kusnekov A.W. and Anisman H., eds., The Wiley-Blackwell Handbook of Psychoneuroimmunology. Chichester: Wiley-Blackwell.
  13. Eisenberger N.I., Inagaki T.K., Rameson L.T., Mashal N.M. and Irwin M.R. (2009). An fMRI study of cytokine-induced depressed mood and social pain: the role of sex differences. Neuroimage, 47(3): 881-90.
  14. Eisenberger N.I., Inagaki T.K., Marshal N.M. and Irwin M.R. (2010a). Infl ammation and social experience: an infl ammatory challenge induces feelings of social disconnection in addition to depressed mood. Brain Behav. Immunol., 24(4): 558-563.
  15. Eisenberger N.I., Berkman E.T., Inagaki T.K., Rameson L.T., Mashal N.M. and Irwin M.R. (2010b). Infl ammation-induced anhedonia: endotoxin reduces ventral striatum responses to reward. Biol. Psychiatry, 68(8): 748-754.
  16. Hackett R.A., Hamer M., Endrighi R., Brydon L. and Steptoe A. (2012). Loneliness and stress-related infl ammatory and neuroendocrine responses in older men and women. Psychoneuroendocrinology, 37(11): 1801-1809.
  17. Inagaki T.K., Muscatell K.A., Irwin M.R., Cole S.W. and Eisenberger N.I. (2012). Infl ammation selectively enhances amygdala activity to socially threatening images. Neuroimage, 59(4): 3222-3226.
  18. Inagaki T.K., Muscatell K.A., Irwin M.R., Moieni M., Dutcher J.M., Jevtic I., Breen E.C. and Eisenberger N.I. (2015). The role of the ventral striatum in infl ammatory-induced approach toward support fi gures. Brain Behav. Immun., 44: 247-252.
  19. Jaremka L.M., Fagundes C.P., Peng J., Bennett J.M., Glaser R., Malarkey W.B. and Kiecolt-Glaser J.K. (2013a). Loneliness promotes infl ammation during acute stress. Psychol. Sci., 24(7): 1089-1097., 10.1177/095679761246405DOI: 10.1177/095679761246405
  20. Jaremka L.M., Fagundes C.P., Glaser R., Bennett J.M., Malarkey W.B. and Kiecolt-Glaser J.K. (2013b). Loneliness predicts pain, depression, and fatigue: understanding the role of immune dysregulation. Psychoneuroendocrinology, 38(8): 1310-1317.
  21. Kirschbaum C., Pirke K. M. and Hellhammer D. H. (1993). The ‘Trier Social Stress Test’ – a tool for investigating psychobiological stress responses in a laboratory setting. Neuropsychobiology, 28(1-2): 76-81., 10.1159/00011900DOI: 10.1159/00011900
  22. McEwen B.S. and Gianaros P.J. (2010). Central role of the brain in stress and adaptation: links to socioeconomic status, health, and disease. Ann. N.Y. Acad. Sci., 1186: 190-222.
  23. Miller G.E., Chen E., Sze J., Marin T., Arevalo J.M., Doll R., Ma R. and Cole S.W. (2008). A functional genomic fi ngerprint of chronic stress in humans: blunted glucocorticoid and increased NF-kappaB signaling. Biol. Psychiatry, 64(4): 266-272.
  24. Miller G.E., Rohleder N. and Cole S.W. (2009a). Chronic interpersonal stress predicts activation of pro- and anti-infl ammatory signaling pathways 6 months later. Psychosom. Med., 71(1): 57-62.
  25. Miller G.E., Chen E. and Cole S.W. (2009b). Health psychology: developing biologically plausible models linking the social world and physical health. Annu. Rev. Psychol., 60: 501-524.
  26. Miller G.E., Chen E., Fok A.K., Walker H., Lim A., Nicholls E.F., Cole S. and Kobor M.S. (2009c). Low early-life social class leaves a biological residue manifested by decreased glucocorticoid and increased proinfl ammatory signaling. PNAS, 106(349: 14716-14721.
  27. Moieni M., Irwin M.R., Jevtic I., Breen E.C., Cho H.J., Arevalo J.M. and Eisenberger N.I. (2015). Trait sensitivity to social disconnection enhances pro-infl amatory responses to a randomized controlled trial of endotoxin. Psychoneuroendocrinology, 62: 336-342.
  28. Muscatell K.A., Moieni M., Inagaki T.K., Dutcher J.M., Jevtic I., Breen E.C., Irwin M.R. and Eisenberger N.I. (2016). Exposure to an infl ammatory challenge enhances neural sensitivity to negative and positive social feedback. Brain Behav Immun., 57: 21-29.
  29. Schultze-Florey C.R., Martínez-Maza O., Magpantay L., Breen E.C., Irwin M.R., Gündel H. and O’Connor M.F. (2012). When grief makes you sick: bereavement induced systemic infl ammation is a question of genotype. Brain Behav. Immun., 26(7): 1066-1071.
  30. Sirigu A. and Duhamel J.R. (2016). Reward and decision processes in the brains of humans and nonhuman primates. Dialogues Clin. Neurosci., 18(1): 45-53.
  31. Slavich G.M., Way B.M., Eisenberger N.I. and Taylor S.E. (2010). Neural sensitivity to social rejection is associated with infl ammatory responses to social stress. PNAS, 107(33): 14817-14822.
  32. Slavich G.M. and Irwin M.R. (2014). From stress to infl ammation and major depressive disorder: a social signal transduction theory of depression. Psychol Bull., 140(3): 774-815.
  33. Slopen N., Kubzansky L.D., McLaughlin K.A. and Koenen K.C. (2013). Childhood adversity and infl ammatory processes in youth: a prospective study. Psychoneuroendocrinology, 38(2): 188-200.
  34. Sterling P. (2012). Allostasis: a model of predictive regulation. Physiol. Behav., 106(1): 5-15.
  35. Van Oort J., Tendolkar I., Hermans E.J., Mulders P.C., Beckmann C.F., Schene A.H., Fernández G. and van Eijndhoven P.F. (2017). How the brain connects in response to acute stress: A review at the human brain systems level. Neurosci. Biobehav. Rev., 83: 281-297.
  36. Willette A.A., Lubach G.R. and Coe C.L. (2007). Environmental context differentially affects behavioral, leukocyte, cortisol, and interleukin-6 responses to low doses of endotoxin in the rhesus monkey. Brain Behav. Immunol., 21(6): 807-815.
  37. Yamakawa K., Matsunaga M., Isowa T., Kimura K., Kasugai K., Yoneda M., Kaneko H. and Ohira H. (2009). Transient responses of infl ammatory cytokines in acute stress. Biol. Psychol., 82(1): 25-32.
  38. Yee J.R. and Prendergast B.J. (2010). Sex-specifi c social regulation of infl amatory responses and sickness behaviors. Brain Behav. Immunol., 24(6): 942-951.

Andrea Minelli, Michael Di Palma, in "PNEI REVIEW" 2/2018, pp. 31-45, DOI:10.3280/PNEI2018-002003

   

FrancoAngeli è membro della Publishers International Linking Association associazione indipendente e no profit per facilitare l'accesso degli studiosi ai contenuti digitali nelle pubblicazioni professionali e scientifiche