Contemporary psychosomatic medicine is based on complex and multicausal view of diseases in general, regardless of their being referred to as psychosomatic or organic disorders. Accordingly, disease-related factors are seen as mediating variables that are reciprocally intertwined at different levels. Epigenetics is recently affirming in research and clinical investigations as a mediating factor between environmental events and disease vulnerability. Evaluating epigenetic mechanisms in psychosomatic medicine can shed light on complex aspects such as the relationship between childhood traumatic events and clinical course of disease in adulthood, from the onset to the chronic maintenance to mortality risk. In this paper, constructs as interpersonal relationships and loneliness are considered as example for a different viewpoint relating past and present, mental events and biological mechanisms, and - eventually - mind and body .
Keywords: Psychosomatics, Epigenetics, Trauma, Interpersonal relationships, Loneliness, Diseases