In the last two decades, immunological research has invaded all other fields of biological knowledge and the medical clinic. However, it is not only the latter that is revolutionized, even psychology and neuroscience are undergoing a strong impact both theoretically and practically. It is now clear that inflammation, supported by the immune system, is an integral part of mental disorders, cognitive-affective, humoral, neurodevelopmental and neurodegenerative. This complexity, to which the Pnei research has made a decisive contribution, has undermined the paradigm that, starting from Macfarlane Burnet, has dominated the immunology of the last sixty years. The reductionist scientific-industrial complex reacts to the crisis by proposing the extension of anti-inflammatory and immunosuppressive drugs to different human pathologies, both physical and psychic, in an attempt to renew the cage in which to force a systemic science
Keywords: Theoretical immunology, Mečnikov, Jerne, Burnet, Reductionism, Psychoneuroendocrineimmunology.