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Hypnosis and psychosomatic medicine: responsiveness of intestinal brain to hyp-notherapy
Journal Title: IPNOSI 
Author/s: Alessandra Grillo, Antonio Piro 
Year:  2019 Issue: Language: Italian 
Pages:  22 Pg. 19-40 FullText PDF:  246 KB
DOI:  10.3280/IPN2019-001002
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We know that the digestive system is equipped with a brain. The unpleasant in-testine is more intellectual than the heart itself and may even have a higher "emo-tional" capacity. The key of stress, anxiety and tension, then, can be found in the bowels. In fact, this is where another true brain is located, with important functions that affect the entire organism that controls emotions, memories and pleasure. The authors of this article, after a general historical and philosophical overview of the relationship between mind and body, list the most recent scientific evidence con-cerning the use of hypnosis techniques for intestinal distress. More specifically, an experimental study that aims to verify the effectiveness of Ericksonian hypnosis on the improvement of the symptomatology that combines together the Inflam-matory Bowel Disease (IBD) and the Irritable Bowel Syndrome (IBS), and that in the meantime points out the importance of spotting specific psychophysiological markers that are useful for the creation of more focused treatments for every pa-tient.
Keywords: Intestinal brain, psychosomatic medicine, intestinal distress, hypnosis, mind, body.

  1. Ader R. (1998). Psychoneuroimmunology, ILAR J., 39(1): 27-29.
  2. Alexander F. (1987). Psychosomatic Medicine: Its Principles and Applications. London: Norton.
  3. Alicino G., Convertino A. (2012). Dialogo mente-corpo/corpo-mente: esiti di salute e prospettive di sostenibilità. Programma Scienziati in Azienda XII. Ediz. Stresa.
  4. Aristotele (2001). L’anima, Libro II, 1, 412. Milano: Bompiani.
  5. Bäckhed F. (2015). Host-bacterial mutualism in the human intestine. Science, 307(5717): 1915-20.
  6. Balint M. (1960). Medico, paziente e malattia. Roma: Giovanni Fioriti Editore.
  7. Ballou S., Keefer L. (2017). Psychological Interventions for Irritable Bowel Syndrome and Inflammatory Bowel Diseases. Clinical and Translational Gastroenterology, 8(1).
  8. Bannaga A., Selinger C.P. (2015). Inflammatory bowel disease and anxiety: links, risks, and challenges faced. Clinical and Experimental Gastroenterology, 23(8): 111-117., DOI: 10.2147/CEG.S57982
  9. Borre Y.E., Moloney R.D., Clarke G., Dinan T.G., Cryan J.F. (2014). The impact of microbiota on brain and behavior: mechanisms & therapeutic potential. Advances in Experimental Medicine and Biology, 817: 373-403., DOI: 10.1007/978-1-4939-0897-4_17
  10. Bottaccioli F. (2005). Psiconeuroendocrinoimmunologia, I fondamenti scientifici delle relazioni mente-corpo. Le basi razionali della medicina integrata. Cesena: Red Edizioni.
  11. Bottaccioli F. (2012) Stress e vita. La scienza dello stress e la scienza della salute alla luce della Psiconeuroendocrinoimmunologia. Milano: Tecniche Nuove Editore.
  12. Bottaccioli F. (2014). Epigenetica e psiconeuroendocrinoimmunologia. Le due facce della rivoluzione in corso nelle scienze della vita. Saggio scientifico e filosofico. Milano: Edra.
  13. Burokas A., Moloney R., Dinan T., Cryan J. (2015). Microbiota regulation of the Mammalian gut-brain axis. Advances in Applied Microbiology, 91: 1-62.
  14. Carabotti M., Scirocco A., Maselli M., Severi C. (2015). The gut-brain axis: interactions between enteric microbiota, central and enteric nervous systems. Annals of Gastroenterology, 28(2): 203-209.
  15. Dalrymple J., Bullock I. (2008). Diagnosi and management of irritable bowel syndrome in adults in primary care: summary of NICE guidance. British Medical Journal, 336(7643): 556-558.
  16. Dinan T., Borre Y., Cryan J. (2014). Genomics of schizophrenia: time to consider the gut microbiome? Molecular Psychiatry, 19: 1252-1257.
  17. Dinan T.G., Cryan J.F. (2015). The impact of gut microbiota on brain and behaviour: implications for psychiatry. Current Opinion in Clinical Nutrition and Metabolic Care, 18(6): 552-558., DOI: 10.1097/MCO.0000000000000221
  18. Drossman D.A. (1998). Presidential address: Gastrointestinal illness and the biopsychosocial model. Psychosomatic Medicine, 60: 258-267., DOI: 10.1097/00006842-199805000-00007
  19. Drossman D.A., Camilleri M., Mayer E., Whitehead W. (2002). AGA technical review on irritable bowel syndrome. Gastroenterology, 123(6): 2108-2131.
  20. Erickson M.H. (1978). Le nuove vie dell’ipnosi. Roma: Astrolabio.
  21. Erickson M.H. (1989). La comunicazione mente-corpo in ipnosi. Seminari, dimostrazioni e conferenze. Roma: Astrolabio.
  22. Farrokhyar F., Marshall J., Easterbrook B., Irvine J. (2006). Functional gastrointestinal disorders and mood disorders in patients with inactive inflammatory bowel disease: Prevalence and impact on health. Inflammatory Bowel Diseases, 12(1): 38-46., DOI: 10.1097/01.MIB.0000195391.49762.89
  23. Fondazione ISTUD, Dialogo mente-corpo/corpo-mente: esiti di salute e prospettive di sostenibilità. Programma Scienziati in Azienda ‒ XII Edizione. Stresa, 2011-2012.
  24. Foster J., Rinaman L, Cryan J. (2017). Stress & the gut-brain axis: Regulation by the microbiome. Neurobiology of Stress, 19(7): 124-136.
  25. Freud S. (1989). Opere Vol. 1: Studi sull’isteria e altri scritti (1886-1895). Torino: Boringhieri.
  26. Furness J., Callaghan B., Rivera L., Cho H. (2014). The enteric nervous system and gastrointestinal innervation: integrated local and central control. Advances in Experimental Medicine and Biology, 817: 39-71., DOI: 10.1007/978-1-4939-0897-4_3
  27. Galland L. (2014). The gut microbiome and the brain. Journal of Medical Food, 17(12): 1261-1272.
  28. Galimberti U. (1987). Il corpo. Milano: Feltrinelli.
  29. Gershon M. (2013). Il secondo cervello. Torino: UTET.
  30. Gorad D., Gomborone J., Libby G., Farthing M. (1996). Intestinal transit in anxiety and depression. Gut, 39(4).
  31. Groddeck G. (2005). Il linguaggio dell’Es. Saggi di psicosomatica e di psicoanalisi dell’arte e della letteratura. Milano: Adelphi.
  32. Hammerman O., Mostofsky D., Louria Y., Ifergane G., Ezra Y. (2016). Tested, but not tried ‒ why is behavioral medicine rarely implemented in clinical practice? Harefua, 155(2): 119-123, 130.
  33. Hata T., Asano Y., Yoshihara K., Kimura-Todani T., Miyata N., Zhang X., Takakura S., Aiba Y., Koga Y., Sudo N. (2017) Regulation of gut luminal serotonin by commensal microbiota in mice. Plos one, 12(7).
  34. Hosseinzadeh S., Poorsaadati S., Radkani B., Forootan M. (2011). Psychological disorders in patients with chronic constipation. Gastroenterology and Hepatology from Bed to Bench, 4(3): 159-163.
  35. Jašarević E., Rodgers A., Bale T. (2015). A novel role for maternal stress and microbial transmission in early life programming and neurodevelopment. Neurobiology of Stress,1: 81-88.
  36. Keefer L., Keshavarzian A. (2007). Feasibility and acceptability of gut-directed hypnosis on inflammatory bowel disease: a brief communication. International Journal of Clinical and Experimental Hypnosis, 55(4): 457-466, DOI: 10.1080/00207140701506565
  37. Levenson J. (2011). The somatoform disorders: 6 characters in search of an author, Psychiatric Clinics of North America, 34(3): 515-524.
  38. Lowen A. (2004). Il linguaggio del corpo. Milano: Feltrinelli.
  39. Lozio L. (2011). Microbiotica intestinale. Preservare il corretto equilibrio dell’intestino. Milano: Tecniche Nuove.
  40. Manuale di gastroenterologia Unigastro, 2007-2009. Roma: EGI.
  41. Mayer E., Tillisch K, Gupta, A. (2015) Gut/brain axis and the microbiota. Journal of Clinical Investigation, 125(3): 926-938., DOI: 10.1172/JCI76304
  42. Mawdsley J., Jenkins D., Macey M., Langmed L., Rampton D. (2008). The effect of hypnosis on systemic and rectal mucosal measures of inflammation in ulcerative colitis. American Journal of Gastroenterology, 103(6): 1460-1469.
  43. Merati L., Mantellini B. (2005). La medicina complementare nella pratica clinica. Masson.
  44. Moloney R., Desbonnet L., Clarke G., Dinan T., Cryan J. (2014). The microbiome: stress, health and disease. Mammaliam Genome, 25(1-2):49-74.
  45. Moser G. (2016). The role of hypnotherapy for the treatment of inflammatory bowel diseases. Expert Review of Gastroenterology & Hepatology, 12: 601-606., DOI: 10.1586/17474124.2014.917955
  46. Moser G., Peter J. (2017). Brain-gut axis and gut-directed hypnosis ‒ success of an integrated psychosomatic treatment in gastroenterology. Zeitschrift fur Psychosomastiche Medizin und Psychotherapie, 63(1): 5-19.
  47. O’Hara A., Shanahan F. (2006). The gut flora as a forgotten organ. EMBO Reports, 7(7): 688-693.
  48. Pancheri P. (1980). Stress Emozioni e Malattia, introduzione alla Medicina Psicosomatica. Milano: Mondadori.
  49. Platone (2014). Fedone. Roma: Laterza.
  50. Quigley E.M., Abdel-Hamid H., Barbara G., Bhatia S., Boeckxstaens G., De Giorgio R., Delvaux M., Foxx-Orenstein A., Guarner F., Gwee K., Harris L., Hungin A., Hunt R., Kellow J., Khalif I., Kruis W., Lindberg G., Olano C., Moraes-Filho J., Schiller L., Schmulson M., Simrén M., Tzeuton C. (2012). A global perspective on irritable bowel syndrome: a consensus statement of the World Gastroenterology Organisation Summit Task Force on irritable bowel syndrome. Journal of Clinical Gastroenterology, 46(5): 356–366.
  51. Reich W. (1994). La biopatia del cancro. Milano: SugarCo.
  52. Rhee S.H., Pothoulakis C., Mayer E.A. (2009). Principles and clinical implications of the brain-gut-enteric microbiota axis. Nature Reviews Gastroenterology & Hepatology, 6: 306–314.
  53. Roberts L., Wilson S., Singh S., Roalfe A., Greenfield S. (2006). Gut-directed hypnotherapy for irritable bowel syndrome: piloting a primary care-based randomised controlled trial. British Journal of General Practice, 56(523): 115-121.
  54. Rutten J., Reitsma J., Vlieger A., Benninga M. (2013). Gut-directed hypnotherapy for functional abdominal pain or irritable bowel syndrome in children: a systematic review. Archives of Disease in Childhood, 98(4): 252-257.
  55. Rutten J., Vlieger A., Frankenhuis C., George E., Groeneweg M., Norbruis O., Tjon A Ten W., Van Wering H., Dijkgraaf M., Merkus M., Benninga M. (2017). Home-Based Hypnotherapy Self-exercises vs Individual Hypnotherapy with a Therapist for Treatment of Pediatric Irritable Bowel Syndrome, Functional Abdominal Pain, or Functional Abdominal Pain Syndrome: A Randomized Clinical Trial. JAMA Pediatric, 171(5): 470-477.
  56. Sarah B., Keefer L. (2017). Psychological Interventions for Irritable Bowel Syndrome and Inflammatory Bowel Diseas. Clinical and Translational Gastroenterology, 8(1): e214.
  57. Selye H. (1970). The evolution of the stress. American Journal of Cardiology, 26: 289-299., DOI: 10.1016/0002-9149(70)90796-4
  58. Spencer N., Hibberd T., Travis L., Wiklendt L., Costa M., Hu H., Brookes S., Wattchow D., Dinning P., Keating D., Sorensen J. (2018). Identification of a rhytmic firing pattern in the enteric nervous system that generates rhytmic electrical activity in smooth muscle. Journal of Neuroscience, 28: 3489-3517., DOI: 10.1523/JNEUROSCI.3489-17.2018
  59. Spiller R., Aziz Q., Creed F., Emmanuel A., Houghton L., Hungin P., Jones R., Kumar D., Rubin G., Trudgill N., Whorwell P. (2007). Guidelines on the irritable bowel syndrome: mechanisms and practical management. BMJ Journals, 56: 1770-1798.
  60. Steinberg H. (2004). Il peccato nel concetto eziologico di Johann Christian August Heinroth (1773-1843) Parte 1: Tra la teologia e la psichiatria Heinroth i concetti di cui essere, libertà, ragione e turbamento dell’anima. Storia della Psichiatria, 15 (59 Pt 3): 329-344. Clinical and Translational Gastroenterology.
  61. Szigethy E. (2015). Hypnotherapy for Inflammatory Bowel Disease Across the Lifespan. American Journal of Clinical Hypnosis, 58(1): 81-99., DOI: 10.1080/00029157.2015.1040112.
  62. Vlieger A., Menko-Frankenhuis C., Wolfkamp S., Tromp E., Benninga M. (2007). Hypnotherapy for children with functional abdominal pain or irritable bowel syndrome: a randomized controlled trial. Gastroenterology, 133(5): 1430-1436.
  63. Von Wietersheim J., Kessler H. (2006). Psychotherapy with chronic inflammatory bowel disease patients: a review. Inflammatory Bowel Diseases, 12(12): 1175-1184.
  64. Whorwell P., Prior A., Faragher E. (1984). Controlled trial of hypnotherapy in the treatment of severe refractory irritable bowel syndrome. Lancet, 2(8414):1232-1234., DOI: 10.1016/S0140-6736(84)92793-4
  65. Zijdenbos I., De Wit N.J, Van der Heijden G., Rubin G., Quartero A. (2009). Psychological treatments for the management of irritable bowel syndrome. Cochrane Database of Systematic Reviews, 21(1): CD006442.

Alessandra Grillo, Antonio Piro, Hypnosis and psychosomatic medicine: responsiveness of intestinal brain to hyp-notherapy in "IPNOSI" 1/2019, pp. 19-40, DOI:10.3280/IPN2019-001002


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