Dialogue between psyche and matter. The new conception of physical reality, based on quan-tum entanglement and "intricacy", on the Mind-Body-World indissoluble relationship, has relevant consequences, analyzed with great acumen by Jung and Pauli in their long (1932-1958) and fruitful exchange of letters, on the dialogue between psyche and matter. And it has a profound implications also on epistemological foundations of modern biology and medi-cine, as Georges Canguilhem showed in his essay The Normal and the Pathological, one of the crucial contributions to the history of science in the last century, which takes as its starting point the conditions determining the particular makeup and structure of biology as a science in the 19th-century.
Keywords: Border, uncertainty, superposition, archetypes, synchronicity, metastability.