Gli psichedelici: quanto è efficace e sicuro il loro possibile impiego in psichiatriae psicoterapia? Lo stato delle evidenze

Titolo Rivista PNEI REVIEW
Autori/Curatori Francesco Dente
Anno di pubblicazione 2023 Fascicolo 2023/1 Lingua Italiano
Numero pagine 17 P. 89-105 Dimensione file 1110 KB
DOI 10.3280/PNEI2023-001006
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Nell’ultimo decennio la ricerca sull’utilizzo terapeutico degli psichedelici ha subito un’impennata, soprattutto per quanto riguarda la loro poten- ziale applicazione nel trattamento dei disturbi psichiatrici. In questi studi è stata indagata la sicurezza e l’efficacia delle varie sostanze psichedeliche, come gli psichedelici classici (psilocibina, ayahuasca e LSD) la ketamina e l’MDMA. Gli studi si sono focalizzati nel trattamento di diversi disturbi psi- chiatrici come la depressione, le dipendenze da sostanza e la sindrome da stress post-traumatico (PTSD). Inoltre, grazie allo sviluppo delle tecniche di neuroimaging è possibile indagare come queste sostanze modulino i di- versi network cerebrali, e come esse sembrino effettuare i loro meccanismi terapeutici. In questo articolo, verranno descritti gli aspetti generali delle diverse sostanze psichedeliche, dalla classificazione ai diversi meccanismi farmacologici sottolineando le differenze tra psichedelici classici e non. Inol- tre, verranno analizzate le diverse componenti della psicoterapia assistita da psichedelici con particolare riguardo alle variabili del set e del setting. Infi- ne, verrà effettuata una revisione della letteratura riguardante gli studi più importanti dell’ultimo decennio sul tema del trattamento di ansia e depres- sione con psichedelici classici e ketamina, dipendenze da sostanze trattate con psichedelici classici e ketamina e trattamento della sindrome da stress post-traumatico con MDMA.;

Keywords:Psichedelici, Psicoterapia-assistita da psichedelici, Setting, Psilo- bicina, Ketamina, MDMA.

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Francesco Dente, Gli psichedelici: quanto è efficace e sicuro il loro possibile impiego in psichiatriae psicoterapia? Lo stato delle evidenze in "PNEI REVIEW" 1/2023, pp 89-105, DOI: 10.3280/PNEI2023-001006