Epigenetics and cancer

Journal title PNEI REVIEW
Author/s Ketti Mazzocco, Alessandra Milani
Publishing Year 2023 Issue 2023/1 Language Italian
Pages 20 P. 68-87 File size 1119 KB
DOI 10.3280/PNEI2023-001005
DOI is like a bar code for intellectual property: to have more infomation click here

Below, you can see the article first page

If you want to buy this article in PDF format, you can do it, following the instructions to buy download credits

Article preview

FrancoAngeli is member of Publishers International Linking Association, Inc (PILA), a not-for-profit association which run the CrossRef service enabling links to and from online scholarly content.

In recent years there has been an increase in the incidence and preva- lence of cancer in Italy and worldwide. The post-pandemic mortality rate is also rising compared to previous years. CoViD-19 has, in fact, created a diagnostic delay and a late start of treatment, thus reducing in many cases the probability of healing. Official Italian websites on cancer information (Aimac, Airc), reports from national associations such as the Italian As- sociation of Medical Oncology (Aiom), and the Ministry of Health "can- cer prevention" website describe the main risk factors of cancer disease; no mention was found about the psychological factors despite the growing evidence on their significant contribution. The following narrative review aims to highlight, through complex epigenetic mechanisms, the influence on carcinogenesis of the most well-known and shared risk factors such as lifestyles and environment, but also of less publicized ones such as social environment and self-perception. This complex multifactoriality of cancer disease may represent an opportunity for healthcare professionals to con- sider a patient as a system consistent with the Pnei perspective and to pro- mote an integrated care.

Keywords: Epigenetics, Cancer, Lifestyle, Environment, Psychology, Integrated care

  1. Airc (2018). Cos’è il cancro. AIRC. -- https://www.airc.it/cancro/informazioni-tumori/ cose-il-cancro/cause-del-cancro recuperato 8 aprile 2023
  2. Aimac (2022). Fattori di rischio - Aimac - Associazione Italiana Malati di Cancro. AIMAC. -- https://www.aimac.it/informazioni-tumori/fattori-rischio-tumori recuperato 8 aprile 2023
  3. Aiom, Airtum, Fondazione Aiom, Osservatorio Nazionale Screening, Passi e Passi d’Argento, & SIAPeC-IAP (2022). I numeri del cancro in Italia 2022. Roma: Inter- media Editore. -- https://www.aiom.it/wp-content/uploads/2022/12/2022_AIOM_NDC- web.pdf
  4. Bottaccioli F., & Bottaccioli A.G. (2020). Psycho Neuro Endocrine Immunology and the science of the integrated care - The manual. Milan: Edra.
  5. Bryan A.D., Magnan R.E., Hooper A.E.C., Harlaar N., & Hutchison K.E. (2013). Physical Activity and Differential Methylation of Breast Cancer Genes Assayed from Saliva: A Preliminary Investigation. Annals of Behavioral Medicine, 45(1), 89–98.
  6. Cervena K., Siskova A., Buchler T., Vodicka P., & Vymetalkova V. (2020). Methyla- tion-Based Therapies for Colorectal Cancer. Cells, 9(6), 1540.
  7. Chhikara B.S., & Parang K. (2023). Global Cancer Statistics 2022: the trends projection analysis. Chemical Biology Letters, 10(1), 451–451. -- https://pubs.thesciencein.org/journal/ index.php/cbl/article/view/451
  8. Cole S.W. (2019). The Conserved Transcriptional Response to Adversity. Current Opi- nion in Behavioral Sciences, 28, 31–37.
  9. Fatma H., Maurya S.K., & Siddique H.R. (2022). Epigenetic modifications of c-MYC: Role in cancer cell reprogramming, progression and chemoresistance. Semi- nars in Cancer Biology, 83, 166–176.
  10. Ferlay J., Colombet M., Soerjomataram I., Parkin D.M., Piñeros M., Znaor A., & Bray F. (2021). Cancer statistics for the year 2020: An overview. International Jour- nal of Cancer, 149(4), 778–789.
  11. Gyamfi J., Kim J., & Choi J. (2022). Cancer as a Metabolic Disorder. International Journal of Molecular Sciences, 23(3), 1155.
  12. Herceg Z., Ghantous A., Wild C.P., Sklias A., Casati L., Duthie S.J., Fry R., Issa J., Kellermayer R., Koturbash I., Kondo Y., Lepeule J., Lima S.C.S., Marsit C.J., Rakyan V., Saffery R., Taylor J.A., Teschendorff A.E., Ushijima T., Vineis P., Walker C.L., Waterland R.A., Wiemels J., Ambatipudi S., Degli Esposti D., & Hernandez-Vargas H. (2018). Roadmap for investigating epigenome deregulation and environmental origins of cancer. International Journal of Cancer, 142(5), 874– 882.
  13. Hussain S., Tulsyan S., Dar S.A., Sisodiya S., Abiha U., Kumar R., Mishra B.N., & Haque S. (2022). Role of epigenetics in carcinogenesis: Recent advancements in anticancer therapy. Seminars in Cancer Biology, 83, 441–451.
  14. Koban L., Gianaros P.J., Kober H., & Wager T.D. (2021). The self in context: brain systems linking mental and physical health. Nature Reviews Neuroscience, 22(5), 309–322.
  15. Lu A., & Wu H. (2015). Structural mechanisms of inflammasome assembly. FEBS Journal, 282(3), 435–444.
  16. Lutgendorf S.K., & Sood A.K. (2011). Biobehavioral Factors and Cancer Progression: Physiological Pathways and Mechanisms. Psychosomatic Medicine, 73(9), 724–730.
  17. Ministero della Salute. (2023). Stili di vita contro il cancro. Ministero della Salute. -- https://www.salute.gov.it/portale/prevenzioneTumori/dettaglioContenutiPrevenzione- Tumori.jsp?lingua=italiano&id=6007&area=prevenzioneTumori&menu=vuoto recupe- rato 9 febbraio 2023
  18. Moreno-Smith M., Lutgendorf S.K., & Sood A.K. (2010). Impact of stress on cancer metastasis. Future Oncology, 6(12), 1863–1881.
  19. Olivier M., Hollstein M., & Hainaut P. (2010). TP53 Mutations in Human Cancers: Origins, Consequences, and Clinical Use. Cold Spring Harbor Perspectives in Biology, 2(1), a001008–a001008.
  20. Özyalçin B., & Sanlier N. (2020). The effect of diet components on cancer with epi- genetic mechanisms. Trends in Food Science & Technology, 102, 138–145.
  21. Pagiatakis C., Musolino E., Gornati R., Bernardini G., & Papait R. (2021). Epige- netics of aging and disease: a brief overview. Aging Clinical and Experimental Research, 33(4), 737–745.
  22. Yang B.-Z., Zhang H., Ge W., Weder N., Douglas-Palumberi H., Perepletchikova F., Gelernter J., & Kaufman J. (2013). Child Abuse and Epigenetic Mechanisms of Disease Risk. American Journal of Preventive Medicine, 44(2), 101–107.
  23. Wu S., Zhu W., Thompson P., & Hannun Y.A. (2018). Evaluating intrinsic and non-in- trinsic cancer risk factors. Nature Communications, 9(1), 3490.
  24. Who. (2022). Cancer. World Health Organization. -- https://www.who.int/news-room/ fact-sheets/detail/cancer recuperato 3 aprile 2023
  25. Wang X., & Sun Q. (2017). TP53 mutations, expression and interaction networks in human cancers. Oncotarget, 8(1), 624–643.
  26. Volden P.A., & Conzen S.D. (2013). The influence of glucocorticoid signaling on tu- mor progression. Brain, Behavior, and Immunity, 30, S26–S31.
  27. Tiffon C. (2018). The Impact of Nutrition and Environmental Epigenetics on Human Health and Disease. International Journal of Molecular Sciences, 19(11), 3425.
  28. Thomas R., Kenfield S.A., Yanagisawa Y., & Newton R.U. (2021). Why exercise has a crucial role in cancer prevention, risk reduction and improved outcomes. British Medi- cal Bulletin, 139(1), 100–119.
  29. Thaker P.H., Han L.Y., Kamat A.A., Arevalo J.M., Takahashi R., Lu C., Jennings N.B., Armaiz-Pena G., Bankson J.A., Ravoori M., Merritt W.M., Lin Y.G., Manga- la L.S., Kim T.J., Coleman R.L., Landen C.N., Li Y., Felix E., Sanguino A.M., New- man R.A., Lloyd M., Gershenson D.M., Kundra V., Lopez-Berestein G., Lutgen- dorf S.K., Cole S.W., & Sood A.K. (2006). Chronic stress promotes tumor growth and angiogenesis in a mouse model of ovarian carcinoma. Nature Medicine, 12(8), 939–944.
  30. Su L.J., Mahabir S., Ellison G.L., McGuinn L.A., & Reid B.C. (2012). Epigenetic Contributions to the Relationship between Cancer and Dietary Intake of Nutrients, Bio- active Food Components, and Environmental Toxicants. Frontiers in Genetics, 2, 91.
  31. Shi M., Du L., Liu D., Qian L., Hu M., Yu M., Yang Z., Zhao M., Chen C., Guo L., Wang L., Song L., Ma Y., & Guo N. (2012). Glucocorticoid regulation of a novel HPV-E6-p53- miR-145 pathway modulates invasion and therapy resistance of cervical cancer cells: Modulation of invasion and therapy resistance of cervical cancer cells. The Journal of Pathology, 228(2), 148–157.
  32. Sharma N., Pasala M.S., & Prakash A. (2019). Mitochondrial DNA: Epigenetics and environment. Environmental and Molecular Mutagenesis, 60(8), 668–682.
  33. Scott A.R., Stoltzfus K.C., Tchelebi L.T., Trifiletti D.M., Lehrer E.J., Rao P., Bleyer A., & Zaorsky N.G. (2020). Trends in Cancer Incidence in US Adolescents and Young Adults, 1973-2015. JAMA Network Open, 3(12), e2027738.
  34. Rahib L., Wehner M.R., Matrisian L.M., & Nead K.T. (2021). Estimated Projection of US Cancer Incidence and Death to 2040. JAMA Network Open, 4(4), e214708.
  35. Radom-Aizik S., Zaldivar F., Oliver S., Galassetti P., & Cooper D.M. (2010). Evidence for microRNA involvement in exercise-associated neutrophil gene expres- sion changes. Journal of Applied Physiology, 109(1), 252–261.
  36. Pu J., Bai D., Yang X., Lu X., Xu L., & Lu J. (2012). Adrenaline promotes cell pro- liferation and increases chemoresistance in colon cancer HT29 cells through induction of miR-155. Biochemical and Biophysical Research Communications, 428(2), 210–215.
  37. Pogribny I.P., & Rusyn I. (2013). Environmental Toxicants, Epigenetics, and Cancer. In: Karpf A. R. (Ed.), Epigenetic Alterations in Oncogenesis (Vol. 754, pp. 215–232). New York, NY: Springer New York. DOI: 10.1007/978-1-4419-9967-2_1

Ketti Mazzocco, Alessandra Milani, Epigenetica e cancro in "PNEI REVIEW" 1/2023, pp 68-87, DOI: 10.3280/PNEI2023-001005