This article is a re-elaboration based on the book Archi-Therapeia. The Influ-ence of Architecture on the PNEI Mind-Body System authored by Silvia Moneti, Architect and Teacher with a Master’s degree in PNEI and Integrated Care Science. In particular, reference is made to the chapter concerning design guidelines for healthcare facilities, with the aim of presenting a set of strategies that can be implemented within care envi-ronments to promote patients’ psychophysical wellbeing. The initial sections address issues related to orientation, accessibility, social interaction, spatial organization and personalization of the patient room. The discussion then proceeds with the presentation of guidelines concerning lighting, acoustics and clinical aromatherapy. The final sections focus on the design of labor and breastfeeding rooms, intensive care units and spaces for home-based care. The article concludes with the hope that the collected evidence may be translated into future architectural projects for healthcare facilities and care environments, while continuing to promote Architecture as a discipline within the PNEI framework and as a form of integrated therapy in its own right.