Looking at Italian smart city projects, this article suggests a theoretical reflection about potentials for an innovative regional cohesiveness condition provided by the exploitation of material and immaterial networks. On this occasion, it presents the outcomes achieved by a research project about the Milan-Turin smart region, that aims at implementing smartness not only in main urban nodes, but also in in-between and non-urban spaces, often marginalized. The project outlines a system of Urban Digital Nodes, which (inspired by a ‘human’ a roach) combine traditional and digital services by referring to specific features and needs of single places and of their users. Conclusions highlight the human smartness potentials and challenges at the regional scale, also in relation to the current debate about the Italian national urban agenda