The cross-talk between peripheral and central infl ammation in depression and the potential for anti-infl ammatory treatments

Journal title PNEI REVIEW
Author/s Maria Antonietta Nettis, Valeria Mondelli
Publishing Year 2018 Issue 2018/2 Language English
Pages 12 P. 60-71 File size 1113 KB
DOI 10.3280/PNEI2018-002005
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Growing evidence suggests that inflammation may be the biological pathway linking physical and psychiatric disorders, such as depression. This evidence has led to the investigation of the antidepressant effect of anti-inflammatory agents, as add-on treatment or as monotherapy. This article reviews the literature about the role of inflammation in depression, with a particular focus on the communication between the peripheral and the central immune system, the role of brain microglia and the blood-brain barrier. In the second part of this manuscript, the Authors review the current evidence on the use of antiinflammatory treatments in depression. The paper concludes by highlighting the unresolved questions and challenges for future studies, such as the need of in vivo models of the link between peripheral and central inflammation and the identification of subgroups of patients with depression that would benefit from anti-inflammatory treatments.

Keywords: Inflammation, Depression, Microglia, Anti-inflammatory agents, Minocycline, Blood-brain barrier.

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Maria Antonietta Nettis, Valeria Mondelli, The cross-talk between peripheral and central infl ammation in depression and the potential for anti-infl ammatory treatments in "PNEI REVIEW" 2/2018, pp 60-71, DOI: 10.3280/PNEI2018-002005