The role of phytonutrition in oncology

Journal title PNEI REVIEW
Author/s Rosaria Ferreri
Publishing Year 2019 Issue 2019/1 Language Italian
Pages 7 P. 15-21 File size 1084 KB
DOI 10.3280/PNEI2019-001003
DOI is like a bar code for intellectual property: to have more infomation click here

Below, you can see the article first page

If you want to buy this article in PDF format, you can do it, following the instructions to buy download credits

Article preview

FrancoAngeli is member of Publishers International Linking Association, Inc (PILA), a not-for-profit association which run the CrossRef service enabling links to and from online scholarly content.

Recent studies have shown that not only the type of diet infl uences the state of infl ammation, the onset of cancer and also its evolution, but especially the use of certain nutrients present in everyday foods: it is precisely on the basis of these researches that you begin to hear about "phytonutrition" in cancer pathologies. In fact, some nutrients act on specifi c mechanisms that have been pointed out as responsible in the process of cancer initiation or promotion. These nutrients could have a role in the prevention but also during the treatments with oncologic drugs, as demonstrated for green tea. The author will examine the principal mechanisms in cancer process giving a suggestion about the best nutrients to use. According to the author, together with a more precise and specifi c cancer therapy there is an important role played by the diet, and the future is in an ever more precise understanding of the metabolic fate of nutrients and their choice in the course of oncologic diseases.

Keywords: Cancer, Metabolism, Inflammation, Nutrients, Antioxidants, Integrated medicine.

  1. Ames B.N. (2006). Low micronutrient intake may accelerate the degenerative diseases of aging through allocation of scarce micronutrients by triage. PNAS, 103(47): 17589-17594.
  2. Bezerra D.P., Militão G.C.G., de Morais M.C. and de Sousa D.P. (2017). The Dual Antioxidant/Proxidant Effect of Eugenol and its Action in Cancer Development and Treatment. Nutrients. 9(12).
  3. Doll R. and Peto R. (1981). The causes of cancer: quantitative estimates of avoidable risks of cancer in the United States today. J. Natl. Cancer Inst., 66(6): 1191-1308.
  4. Duffya M.J., Murraya A.,. Synnott N.C., O’Donovanc N. and Crownd J. (2017). Vitamin D analogues: Potential use in cancer treatment. Crit. Rev. Oncol. Hematol., 112: 190-197.
  5. Khan N., Afaq F., Saleem M., Ahmad N. and Mukhtar H. (2006). Targeting multiple signaling pathways by green tea polyphenol (-)-epigallocatechin-3-gallate. Cancer Res., 66(5): 2500-2505. DOI: 10.1158/0008-5472.CAN-05-363
  6. Patterson B.R.E., Flatt S.W., Newman V.A., Natarajan L., Rock C.L., Thomson C.A., Caan B.J., Parker B.A., and Pierce J.P. (2011). Marine Fatty Acid Intake Is Associated with Breast Cancer Prognosis. J. Nutr., 141(2): 201-206. jn.110.128777
  7. Petiwala S.M. and Johnson J.J. (2015). Diterpenes from rosemary (Rosmarinus offi cinalis): Defi ning their potential for anti-cancer activity. Cancer Lett., 367(2): 93-102.
  8. Plumb J.A., Luo W. and Kerr D.J. (1993). Effect of polyunsaturated fatty acids on the drug sensitivity of human tumour cell lines resistant to either cisplatin or doxorubicin. Br. J. Cancer, 67: 728-733.
  9. Rajamanickam S. and Agarwal R. (2008). Natural products and colon cancer: current status and future prospects. Drug Dev. Res., 69(7): 460-471.
  10. Rhodes M.J.C. (1996). Physiologically-active compounds in plant foods: an overview. Proc. Nutr. Soc., 55(1B): 371-84. DOI: 10.1079/PNS1996003
  11. Riediger N.D., Othman R.A., Suh M. and Moghadasian MH. (2009). A systemic review of the roles of n-3 fatty acids in health and disease. J. Am. Diet. Assoc., 109(4): 668-679.
  12. Santini A. and Novellino E. (2014). Nutraceuticals: Beyond the Diet Before the Drugs. Curr. Bioact. Compd., 10(1): 1-12. DOI: 10.2174/15734072100114072414592
  13. Sartippour M.R., Pietras R., Marquez-Garban D.C., Chen H.W., Heber D., Henning S.M., Sartippour G., Zhang L., Lu M., Weinberg O., Rao J.Y. and Brooks M.N. (2006). The combination of green tea and tamoxifen is effective against breast cancer. Carcinogenesis, 27(12): 2424-2433.
  14. Verhoeven D.T., Goldbohm R.A., van Poppel G., Verhagen H. and van den Brandt P.A. (1996). Epidemiological studies on brassica vegetables and cancer risk. Cancer Epidemiol. Biomarkers Prev., 5(9): 733-748.
  15. WHO (2017). Global Database on Child Growth and Malnutrition. Testo disponibile al sito: --, consultato il 19/05/2018.

Rosaria Ferreri, Il ruolo della fitonutrizione in oncologia in "PNEI REVIEW" 1/2019, pp 15-21, DOI: 10.3280/PNEI2019-001003