L’ossigeno-terapia iperbarica applicata all’autismo: dagli studi internazionali all’esperienza italiana

Titolo Rivista PNEI REVIEW
Autori/Curatori Roberto Vecchione, Nadia Picariello
Anno di pubblicazione 2017 Fascicolo 2017/1 Lingua Italiano
Numero pagine 13 P. 79-91 Dimensione file 1116 KB
DOI 10.3280/PNEI2017-001009
Il DOI è il codice a barre della proprietà intellettuale: per saperne di più clicca qui

Qui sotto puoi vedere in anteprima la prima pagina di questo articolo.

Se questo articolo ti interessa, lo puoi acquistare (e scaricare in formato pdf) seguendo le facili indicazioni per acquistare il download credit. Acquista Download Credits per scaricare questo Articolo in formato PDF

Anteprima articolo

FrancoAngeli è membro della Publishers International Linking Association, Inc (PILA)associazione indipendente e non profit per facilitare (attraverso i servizi tecnologici implementati da CrossRef.org) l’accesso degli studiosi ai contenuti digitali nelle pubblicazioni professionali e scientifiche

La neuroimaging (PET, SPECT, fRMI, DTI) condotta in soggetti autistici ha evidenziato come alcune aree cerebrali, correlate alle espressioni cliniche di tali soggetti, manifestino anomalie sia a carico della sostanza grigia (ipoperfusione) che della sostanza bianca (aberrazioni sinaptiche). Presentiamo l’esperienza del nostro Centro Iperbarico che, inizialmente a carattere osservazionale, si è concretizzata con la pubblicazione di uno studio sulla rivista IJCR. Trenta bambini con disturbo dello spettro autistico (ASD) sono stati sottoposti a HBOT (hyperbaric oxygen therapy) e successivamente valutati con scale psicometriche standardizzate. Risultati: sono emersi miglioramenti delle abilità visuo-motorie, del linguaggio recettivo, dello "Shift"-capacità cognitiva-, del funzionamento adattivo e dei comportamenti-problema succitati: irritabilità, ritiro sociale, stereotipie, iperattività, linguaggio inappropriato, livello di attenzione e di presenza. Conclusioni: L’HBOT si è rivelata effi cace e sicura.;

Keywords:Disordini dello spettro autistico (DSA), ossigeno-terapia iperbarica (OTI)

  1. Bailey A, Luthert P, Dean A, et al. (1998) A clinicopathological study of autism, Brain 121(Pt 5):889-905. doi.org/10.1093/brain/121.5.889
  2. Alexander AL, Lee JE, Lazar M, et al. (2007) Diffusion tensor imaging of the corpus callosum in Autism, Neuroimage 34(1):61-73. doi.org/10.1186/s12906-016-1416-2
  3. Allison T, Puce A e McCarthy G (2000) Social perception from visual cues: role of the STS region, Trends Cogn Sci 4(7):267-278. doi.org/10.1016/S1364-6613(00)01501-1
  4. American Psychiatric Association (1994), Diagnostic and Statistical Manual of Mental Disorders. 4th ed, American Psychiatric Press, Washington, DC.
  5. Assaf Y e Pasternak O (2008) Diffusion tensor imaging (DTI)-based white matter mapping in brain research: a rewiew, J Mol Neurosci 34(1):51-61. doi.org/10.1007/s12031-007-0029-0
  6. Baird G, Simonoff E, Pickles A, et al. (2006) Prevalence of disorders of the autism spectrum in a population cohort of children in South Thames: the Special Needs and Autism Project (SNAP), The Lancet 368(9351):210-215. doi.org/10.1016/S0140-6736(06)69041-7
  7. Ben Bashat D, Kronfeld-Duenias V, Zachor DA, et al. (2007) Accelerated maturation of white matter in young children with autism: A high b value DWI study, Neuroimage 37:40-47. doi.org/10.1016/j.neuroimage.2007.04.060
  8. Bent S, Bertoglio K, Ashwood P, et al. (2012) Brief report: Hyperbaric oxygen therapy (HBOT) in children with autism spectrum disorder: a clinical trial, J Autism Dev Disord 42(6):1127-1132. doi.org/10.1007/s10803-011-1337-3
  9. Boddaert N, Chabane N, Barthelemy C, et al. (2002) Bitemporal lobe dysfunction in infantile autism: positron emission tomography study, J Radiol 83(12 pt 1):1829-1833. doi.org/JR-12-2002-83-12-C1-0221-0363-101019-ART5
  10. Boddaert N e Zilbovicius M (2002) Functional neuroimaging and childhood autism, Pediatr Radiol 32(1):1-7. doi.org/10.1007/s00247-001-0570-x
  11. Chou KH, Cheng Y, Chen IY, et al. (2011) Sex-linked white matter microstructure of the social and analytic brain, Neuroimage 54:725-733.doi.org/10.1016/j.neuroimage.2010.07.010
  12. Chungpaibulpatana J, Sumpatanarax T, Thadakul N, et al. (2008) Hyperbaric oxygen therapy in Thai autistic children, J Med Assoc Thai 91(8):1232-1238.
  13. Conturo TE, Williams DL, Smith CD, et al. (2008) Neuronal fi ber pathway abnormalities in autism: An initial MRI diffusion tensor tracking study of hippocampo-fusiform and amygdalo-fusiform pathways, J Int Neur Soc 14:933-946. doi.org/10.1017/S1355617708081381
  14. Frazier TW e Hardan AY (2009) A Meta-Analysis of the Corpus Callosum in Autism, Biol Psychiatry 66(10):935-941. doi.org/10.1016/j.biopsych.2009.07.022
  15. Gendry Meresse I, Zilbovicius M, Boddaert N, et al. (2005) Autism severity and temporal lobe functional abnormalities, Ann Neurol 58(3):466-469. doi.org/10.1002/ana.20597
  16. George MS, Costa DC, Kouris K, et al. (1992) Cerebral blood fl ow abnormalities in adult with infantile autism, J Nev Ment Dis 180(7):413-417. doi.org/10.1097/00005053-199207000-00002
  17. Ghanizadeh A (2012) Hyperbaric oxygen therapy for treatment of children with autism: a systematic review of randomized trials, Med Gas Res 2:13. doi.org/10.1186/2045-9912-2-13
  18. Golden ZL, Neubauer R, Golden CJ, et al. (2002) Improvement in cerebral metabolism in chronic brain-injury after Hyperbaric oxygen, Neurosci 112(2):119-131. doi.org/10.1080/00207450212027
  19. Granpeesheh D, Tarbox J, Dixon DR, et al. (2010) Randomized trial of hyperbaric oxygen therapy for children with autism, Res Autism Spectr Disord 4:268-275. doi.org/10.1016/j.rasd.2009.09.014
  20. Gulec B, Yasar M, Yldiz S, et al. (2004) Effect of hyperbaric oxygen on experimental acute distal colitis, Physiol Res 53(5):493-499.
  21. Hall G, Szechtman H e Nahmias C (2003) Enhanced Salience and Emotion Recognition in Autism: A PET Study, Am J Psychiatry 160:1439-1441. doi.org/10.1176/appi.ajp.160.8.1439
  22. Harch PG, Kriedt C, Van Meter KW, et al. (2007) Hyperbaric oxygen therapy improves spatial learning and memory in a rat model of chronic traumatic brain injury, Brain Res 1174:120-129. doi.org/10.1016/j.brainres.2007.06.105
  23. Haznedar MM, Buchsbaum Monte S, Metzger M, et al. (1997) Anterior Cingulate Gyrus Volume and Glucose Metabolism in Autistic Disorder, Am J Psychiatry 154:1047-1050. doi.org/10.1176/ajp.154.8.1047
  24. Herbert MR, Ziegler DA, Deutsch CK, et al. (2003) Dissociations of cerebral cortex, subcortical and cerebral white matter volumes in autistic boys, Brain 126:1182-1192. doi.org/10.1093/brain/awg110
  25. Heuser G, Heuser SA, Rodelander D, et al. (2002) Treatment of Neurologically impaired adults and children with “mild” hyperbaric oxygen (1.3 ATA and 24% oxygen), in: Tonier
  26. JT (ed.) 2002, The Proceeding of the 2nd International Symposium on Hyperbaric Oxygenation in Cerebral Palsy and the Brain-Injured Child, Best Publishing Company, North Palm Beach, FL.
  27. Holbach KH, Caroli A e Wassmann H (1977) Cerebral energy metabolism in patients with brain lesions of normo and hyperbaric oxygen pressures, J Neur 21(1):17-30. doi.org/10.1007/BF00316313
  28. Jacobson I e Harper DG (1963) The effect of oxygen under pressure blood fl ow and cerebral venous oxygen tension, The Lancet 2:549. doi.org/10.1016/S0140-6736(63)92644-8
  29. Jacobs EA, Winter PM, Alvis HJ, et al. (1969) Hyperoxygenation effect on cognitive functioning in the aged, N England J Med 281(14):753-757. doi.org/10.1056/NEJM196910022811402
  30. Jepson B, Granpeesheh D, Tarbox J, et al. (2011) Controlled evaluation of the effects of hyperbaric oxygen therapy on the behavioral of 16 children with autism spectrum disorders, J Autism Dev Disord, 41(5):575-88. doi.org/10.1007/s10803-010-1075-y
  31. Kinaci C, Alan M e Hatipoglu K (2007) Brain Perfusion Changes After Hyperbaric Oxygen Theraphy in The Children With Autism, 33rd Annual Scientifi c Meeting of the European Underwater and Baromedical Society on Diving & Hyperbaric Medicine Sharm el-Sheikh, Sinai, Egypt.
  32. Kot J e Mathieu D (2011) Controversial Issues in Hyperbaric Oxygen Therapy: a European Committee for Hyperbaric Medicine Workshop, Diving Hyperb Med 41(2):101-104.
  33. Learch RM, Rees PJ e Wilmshurst P (1998) Hyperbaric oxygen therapy, BMJ317(7166):1140-1143. doi.org/10.1136/bmj.317.7166.1140
  34. Lee JE, Bigler ED, Alexander AL, et al. (2007) Diffusion tensor imaging of white matter in the superior temporal gyrus and temporal stem in autism, Neuroscience Letters 424:127-132. doi.org/10.1016/j.neulet.2007.07.042
  35. McGinnis WR (2004) Oxidative stress in autism, Altern Ther Health Med 10(6):22-36.
  36. Neubauer RA, Gottlieb SF e Miale A Jr (1992) Identifi cation of hypometabolic areas in the brain using imaging and hyperbaric oxygen, Clin Nucl Med 17(6):477-481.
  37. Ohnishi T, Matsuda H, Hashimoto T, et al. (2000) Abnormal regional cerebral blood flow in childhood autism, Brain 123(Pt9):1838-1844. doi.org/10.1093/brain/123.9.1838
  38. Onore C, Careaga M e Ashwood P (2012) The role of immune dysfunction in the pathophysiology of autism, Brain Behav Immun 26(3):383-392. doi.org/10.1016/j.bbi.2011.08.007
  39. Qibiao W, Hongjun W, Linzheng C, et al. (1995) Treatment of Children’s Epilepsy by Hyperbaric Oxygenation: Analysis of 100 cases, in: Cramer FS (ed.) 1995, Proc 11th International Congress on Hyperbaric Medicine Fuzhou, China, Best Publishers Flagstaff, Arizona.
  40. Ratajczak HV (2011) Theoretical aspects of autism: causes--a review, J Immunotoxicol 8(1):68-79. doi.org/10.3109/1547691X.2010.545086
  41. Rossignol DA, Rossignol LW, James SJ, et al. (2007) The effects of hyperbaric oxygen therapy on oxidative stress, infl ammation, and symptoms in children with autism: an open-label pilot study, BMC Pediatr 7:36. doi.org/10.1186/1471-2431-7-36
  42. Rossignol DA (2008) The use of hyperbaric oxygen therapy in autism, in: Zhang JH e Flagstaff AZ (eds.) 2008, Hyperbaric oxygen for neurological disorders, Best Publishing Company, North Palm Beach, FL, pp. 209-288.
  43. Rossignol DA, Rossignol LW, Smith S, et al. (2009) Hyperbaric treatment for children with autism: a multicenter, randomized, double-blind, controlled trial, BCM Pediatr 9:21. doi.org/10.1186/1471-2431-9-21
  44. Rossignol DA, Bradstreet JJ, Van Dyke K, et al. (2012) Hyperbaric oxygen treatment in autism spectrum disorders, Med Gas Res 2(1):16. doi.org/10.1186/2045-9912-2-16
  45. Sahyoun CP, Belliveau JN, Soulières I, et al. (2010) Neuroimaging of the functional and structural networks underlying visuospatial vs. linguistic reasoning in high-functioning autism, Neuropsychologia 48:86-95. doi.org/10.1016/j.neuropsychologia. 2009.08.013
  46. Sampanthavivat M, Singkhwa W, Chaiyakul T, et al. (2012) Hyperbaric oxygen in the treatment of childhood autism: a randomised controlled trial, Diving Hyperb Med 42(3):128-133.
  47. Schultz RT (2008) Neuroimaging Research in Autism: The Next Decade, Autism Res 1:317-319. doi.org/10.1002/aur.58
  48. Starkstein SE, Vazquez S, Vrancic D, et al. (2000) SPECT fi ndings in mentally retarded autistic individuals, J Neuropsychiatr Clin Neurosci 12(3):370-375. doi.org/10.1176/jnp.12.3.370
  49. Thom SR, Bhopale VM, Velazquez OC, et al. (2006) Stem cell mobilization by hyperbaric oxygen, Am J Physiol Heart CircPhysiol 290(4):H1378-H1386. doi.org/10.1152/ajpheart.00888.2005
  50. Vargas DL, Nascimbene C, Krishnan C, et al. (2005) Neuroglial activation and neuroinfl ammation in the brain of patients with autism, Ann Neurol 57(1):67-81. doi.org/10.1002/ana.20315
  51. Wallace DJ, Silverman S, Goldstein J, et al. (1995) Use of hyperbaric oxygen in rheumatic diseases: case report and critical analysis, Lupus 4(3):172-175. doi.org/10.1177/096120339500400302
  52. Wilcox J, Tsuang MT, Ledger E, et al. (2002) Brain perfusion in autism varies with age, Neuropsycobiology 46(1):13-16. doi.org/10.1159/000063570
  53. Yang YJ, Wang XL, Yu XH, et al. (2008) Hyperbaric oxygen induced endogenous neural stem cells to proliferate and differentiate in hypoxic-ischemic brain damage in neonatal rats, Undersea Hyperb Med 35(2):113-129.
  54. Yu XH, Yang, Wang X, et al. (2006) Effect of hyperbaric oxygenation on neural cells and myelin in neonatal rats with hypoxic-ischemic brain damage, Zhongguo Dang Dai ErKe Za Zhi 8(1):33-37.
  55. Zannini D e Vlewicz K (1986) Ossigenoterapia iperbarica ed immunopatologia, in: Atti del VII Congresso Nazionale di Medicina Subacquea e Iperbarica, Palermo, pp. 172-181.
  56. Zilbovicius M, Boddaert N, Belin P, et al. (2000) Temporal lobe dysfunction in childhood autism: a PET study. Positron emission tomography, Am J Psychiatry 157(12):1988-1993. doi.org/10.1176/appi.ajp.157.12.1988
  57. Zilbovicius M, Meresse I e Boddaert N (2006) Autism: Neuroimaging, Rev Bras Psiquiatr 28(Suppl I):S21-S28. doi.org/S1516-44462006000500004

Roberto Vecchione, Nadia Picariello, L’ossigeno-terapia iperbarica applicata all’autismo: dagli studi internazionali all’esperienza italiana in "PNEI REVIEW" 1/2017, pp 79-91, DOI: 10.3280/PNEI2017-001009